The Church of Our Lady of Liesse (Maltese: Knisja tal-Madonna ta' Liesse) is a church in Valletta, Malta. The church was built in 1740 on the site of a 17th-century church. The cupola was built to the design of the Maltese architect Francesco Zammit. The church is located on the waterfront of the Grand Harbour, close to Lascaris Battery and the site of the fish market. It is especially venerated by the people of the port area.