The parish of Xaghra was established by Bishop Cocco-Palmeri on 28 April 1688. The parish was originally sited in the chapel of Saint Antony Abbot in the same village. The present church, like many others, grew over and around an older building first recorded late in the seventeenth century. The foundation stone of the present structure was laid on 2 October 1815. It was consecrated on 26 May 1878 and was raised to Archipresbyteral status on 11 March 1893. The fourth Collegiate of Gozo was established at Xaghra on 17 March 1900. The title of Basilica was conferred on the parish on 26 August 1967.